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Casa Grande

About Us

Casa Grande, located in Knoxville, IA, is your go-to destination for authentic Mexican cuisine bursting with flavor. We are committed to using the freshest ingredients to craft dishes of exceptional quality. Our vibrant atmosphere complements our diverse menu, which includes delectable fajitas, burritos, tacos, seafood platters, and chimichangas, paired with our signature margaritas. Enjoy our full-service bar and event room, perfect for hosting special occasions. Serving Des Moines, Pella, Grinnell, Urbandale, and Ankeny, IA, we invite you to savor the delightful offerings at Casa Grande. Visit us today!

Our Story

Casa Grande is a vibrant Mexican Restaurant located in Knoxville, IA. As a leading establishment in the local culinary scene, we take pride in providing our customers with an exceptional dining experience. With our extensive menu boasting a wide variety of authentic Mexican dishes, we strive to exceed your expectations with every bite.

At Casa Grande, we specialize in traditional Mexican cuisine, offering a diverse selection of A La Carte favorites. Our birria, tacos, tortas, soups, salads, enchiladas, chimichangas, burritos, steaks, pork dishes, chicken dishes, fajitas, seafood platters, and street tacos are expertly crafted using only the freshest ingredients and traditional cooking techniques. Each dish is a culinary masterpiece, bursting with flavors that transport you straight to the streets of Mexico.

To complete your dining experience, Casa Grande also offers a comprehensive beverage menu. Cool down and relax with our refreshing margaritas, perfectly mixed to your liking. We also offer a wide selection of beers, including draft beer, as well as an assortment of spirits and liquors to complement your meal.

Whether you're looking for a cozy dinner date or a fun family outing, Casa Grande welcomes you with open arms. Our comfortable and inviting atmosphere provides the ideal setting for any occasion. Enjoy our friendly and attentive service as we cater to your every need, making sure that your visit is nothing short of exceptional.

To accommodate different preferences and lifestyles, Casa Grande offers a range of service options. Dine-in and savor the warm ambiance and delicious aromas that fill our restaurant. If you're on the go, our convenient take-out service ensures that you can enjoy our delectable dishes wherever you choose. For those who prefer to dine at home, our prompt and efficient delivery service brings the taste of Mexico right to your doorstep.

We understand that celebrating special moments with loved ones is important, which is why Casa Grande also offers a party room for hosting private events. Whether it's a birthday party, family reunion, or corporate gathering, our dedicated staff will ensure that your event is a memorable one, complete with fantastic food and great ambiance.

At Casa Grande, we believe that everyone should be able to enjoy the flavors of Mexico, regardless of age. That's why we have designed a special kids' menu featuring tasty and wholesome options that are sure to put a smile on your little one's face.

To cater to different appetites and budgets, Casa Grande also offers enticing lunch specials, making it the perfect spot for a quick and satisfying midday meal.

With its expansive menu, excellent service, and inviting atmosphere, Casa Grande is the go-to destination for Mexican cuisine in Knoxville, IA. Come and join us today, and let us take you on a culinary journey that will leave you craving for more.

Areas Served

Knoxville, IA | Des Moines, IA | Pella, IA | Grinnell, IA | Urbandale, IA | Ankeny, IA | West Des Moines, IA

Languages Spoken

What We Offer

Our Specialties include:

Our Services include:

Our Brands include:

Our Products include:

Testimonials

On 3/24/2026 Sherry Turner had this to say:
Love this place

On 3/11/2026 Kyle Thorson had this to say:
We went with carry out this time the food was hot and very tasty.

On 3/10/2026 Alex Hlavacek had this to say:
Our favorite Mexican restaurant around! The service is always great, our food always warm, and the speed in which you get your food is amazing! Love this place

On 10/3/2025 Ron Brees had this to say:
Good food and great service

On 9/29/2025 April G Callahan Wolfe had this to say:
Great food, great service. We like the environment.

Contact Us

Casa Grande
110 E Main St Knoxville, IA 50138
Phone: (641) 842-3800
Fax: (515) 255-7050
Email: carmelosantos717@gmail.com

Where To Find Us

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Payment Types Accepted

American Express, Apple Pay, Debit Cards, Discover, MasterCard, Visa

Our Hours

Holiday Hours May Vary. Please Call For Details.

Monday: 11:00 AM - 9:00 PM
Tuesday: 11:00 AM - 9:00 PM
Wednesday: 11:00 AM - 9:00 PM
Thursday: 11:00 AM - 9:00 PM
Friday: 11:00 AM - 10:00 PM
Saturday: 11:00 AM - 10:00 PM
Sunday: 11:00 AM - 8:30 PM

News

No green beer needed — we’ve got margaritas, tacos, fajitas, and all your Mexican favorites waiting for you. Gather your friends and enjoy a festive meal full of flavor and fun.
Stop by and make your St. Patrick’s Day delicious.
📍 Knoxville, IA
📞 641‑842‑3800

Family night out or quiet dinner in? Casa Grande's got you covered! Dive into our savory Soups and fresh Salads, perfect for any taste. And for those seeking the ultimate refreshment, our full-service bar is where the magic happens. 🍲🥗 Book your table or grab some DoorDash tonight! Drink in the good times with our top-notch Margaritas. 🍹

Hey hot stuff! 🌶 Knoxville's tastiest Mexican eats are calling your name at Casa Grande! Don't miss out on our mouthwatering Tortas and sizzling Pork Dishes, best enjoyed with a cold draft beer. 🍺 Bring your friends and kick back in our cozy bar seating or order via Uber Eats for the ultimate night in. You deserve this! 🎉

🎆 Happy 4th of July from all of us at Casa Grande! 🇺🇸✨ We will be closed on 7/4 to celebrate this special day with our loved ones. Wishing you a spectacular Independence Day filled with fireworks, joy, and cherished moments. Remember to stay safe and savor every moment! #Happy4th #IndependenceDay 🎉🎇

🎉 Spice up your day with Casa Grande’s A La Carte selection, perfect for sampling a little bit of everything you love! Dive into our savory Tacos, sizzling Fajitas, and the zest of our Birria. Complement your meal with one of our refreshing Margaritas. Cheers to delicious moments! 🍸 Order now or dine in with us. 🌞 #CasaGrandeKnoxville #MexicanCuisine #Tacos #Fajitas

Info

Drinks + Lunch Menu

FAQ

What type of cuisine does Casa Grande serve?
Casa Grande specializes in authentic Mexican cuisine, offering a variety of dishes such as tacos, enchiladas, burritos, fajitas, and house specialties made with fresh ingredients.
Do you offer takeout or delivery?
Yes! Casa Grande typically offers takeout services. Delivery may be available through local food delivery platforms - check with the restaurant directly or visit our website for options.
Are vegetarian or gluten-free options available?
Yes, many Mexican dishes can be customized to accommodate dietary preferences. Casa Grande likely offers vegetarian options and may be able to adjust meals for gluten-free needs upon request.
Can I host a party or event at Casa Grande?
Casa Grande may offer space for small gatherings or special events. Contact the restaurant to inquire about group reservations, catering options, or private dining availability.
What are your hours of operation?
We are open 7 days a week; Monday through Thursday 11am - 9pm, Friday & Saturday 11am - 10pm, and Sunday 11am - 8:30pm. Hours may vary by location and day of the week. It’s best to check Casa Grande’s website or call the restaurant directly for the most accurate and up-to-date schedule.

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